What Is RET Antibody?
The Ret proto-oncogene (c-Ret) is an ectodomain-containing receptor tyrosine kinase which is a multicomponent receptor complex that is in sync with other membrane-bound ligand-binding GDNF families of receptors. The ligands that interact with the Ret receptor are neurotrophic factor derived from glial cells (GDNF) as well as its cousins, neurturin and persephin as well as artemin.
Research has shown that the changes in the Ret gene can be linked to disorders such as papillary thyroid cancer and multiple endocrine neoplasias (type 2A or 2B) and familial medullary thyroid cancer, and a developmental disorder that is congenital called Hirschsprung's disease. You can also know more about anti-RET antibody Picoband via Bosterbio.
The Tyr905 residue in the Ret Kinase domain has an essential function in Ret biological and catalytic activity. The substitution of Phe to Tyr at 905 significantly blocks Ret auto phosphorylation. RET is an element of the cadherin superfamily. It is the encoding gene for one receptor tyrosine-kinases which are cell-surface proteins which transmit signals for cell expansion and differentiation.
RET is a key player in the development of the neural crest, and may undergo oncogenic activation in vivo as well as in the laboratory through the cytogenetic rearrangement. Variations of the RET gene are linked to the conditions called multiple endocrine neoplasia Type IIA, Multiple endocrine neoplasia kind IIB Hirschsprung disorder, medullary Thyroid cancer.
Two transcript variants that encode different forms have been identified with respect to the RET gene. Other transcript variants have been identified for RET however their biological significance is not confirmed.